Keynote Speaker I
Prof.
Hiroyuki Nakamura
Tokyo Institute of Technology, Japan
Hiroyuki Nakamura was received his PhD from Tohoku
University under the supervision of Professor Yoshinori
Yamamoto in 1996. He became an assistant professor at Kyushu
University (1995-1997) and at Tohoku University (1997-2002).
He worked as a visiting assistant professor at University of
Pittsburgh with Professor D. Curran (2000-2001). In 2002, he
was appointed as an associate professor at Gakushuin
University and promoted as a professor in 2006. In 2013, he
was appointed as a professor at Tokyo Institute of
Technology. He received the Chemical Society of Japan Award
for Young Chemists in 1999 and the Incentive Award of the
Japanese Society for Molecular Target Therapy of Cancer in
2007. He became president of the Japanese Society of Neutron
Capture Therapy in 2015. His research interests include
synthetic methodology, medicinal chemistry, chemical
biology, photodynamic therapy, and neutron capture therapy.
Speech Title: Protein Engineering Using Chemical Labeling Technology
Abstract: Modification of proteins with synthetic chemical probes has become an important technique not only for understanding protein functions, dynamics and cross-talks in cells but also for protein-based therapy in medicine.[1] In general, conventional chemical modifications use nucleophilic substitution of activated electrophilic chemical probes at nucleophilic amino acid residues such as lysine and cysteine residues. Although these modification techniques have been widely used for protein engineering, the generating amide bonds between nucleophilic amino acid residues and electrophilic chemical probes are sometimes labile against various enzymes under physiological conditions. We have recently developed two types of tyrosine residue-specific modification chemical probes, N’-acyl-N,N-dimethyl-phenylenediamines and 1-methyl-4-arylurazoles, activated by ruthenium photocatalyst (Ru(bpy)3) as a single-electron transfer (SET) catalyst to form a covalent bond at the phenolic hydroxy ortho carbon of tyrosine residue. Using these chemical probes, we succeeded in target protein-selective labeling in a protein mixture using a ligand-directed Ru(bpy)3 catalyst.[2-4] Furthermore, our recent study revealed that 1-methyl-4-arylurazoles have shorter distance (a few nanometers) of the SET reaction induced by ruthenium complexes, resulting in more selective labelling and identification of target proteins.
Keynote Speaker II
Prof. King- Chuen Lin
National Taiwan University, Taiwan
King-Chuen Lin is a Distinguished Professor of the
Department of Chemistry at National Taiwan University and a
Distinguished Research Fellow of National Science Council,
Taiwan. He received his B.S. degree in Chemistry from
National Taiwan University, Taiwan, his PhD in Chemistry
from Michigan State University, USA, and his postdoctoral
career at Cornell University. His research interests are
photodissociation and reaction dynamics in gas and condensed
phases, atmospheric chemistry, materials designed for
sensors and catalysts, and single molecule spectroscopy. He
received Academic Award of Ministry of Education, Taiwan, in
2014, and Richard B. Bernstein Award in International
Conference on Stereodynamics-2018. He now serves as an
Associate Editor for J. Chin. Chem. Soc.(Taipei) and a
member of Editorial Board for Scientific Reports (Nature
publisher), Journal of Analytical and Bioanalytical
Techniques (Gavin Publishers), and J. of Modern Chemical
Sciences (Herald Scholarly Open Access).
He has published more than 202 peer-reviewed papers and
edited one book on reaction dynamics and chemical kinetics.
Speech Title: Synthesis and characterization of nanomaterials in applications of sensing and catalysis
Abstract: Palladium nanoparticles (Pd NPs) immobilized on a garlic skin-derived activated carbons (GACs) was synthesized. The morphology, structure, surface compositions, and textural properties of the GACs and Pd@GAC catalyst were examined by a variety of physicochemical characterization techniques which revealed a dispersion of Pd NPs with average particle size of ca. 21 nm on sheet-like graphitized GACs. The Pd@GAC catalyst, which can be facilely prepared with biowaste feedstocks, exhibited excellent catalytic performances for efficient reduction of Cr(VI) with extraordinary stability and recyclability over at least five repeated catalytic test cycles. On the other hand, we report the synthesis, characterization, and catalytic application of ruthenium nanoparticles (Ru NPs) supported on plastic-derived carbons (PDCs) synthesized from plastic wastes (soft drink bottles) as an alternative carbon source. The catalytic activity of Ru@PDC for the reduction of potassium hexacyanoferrate(III), (K3[Fe(CN)6]), and new fuchsin (NF) dye by NaBH4 was performed under mild conditions.
